Overview of Subprojects

I. Comparative Proteomics and RNA Expression Profiling in Mouse Models for Neurodegenerative Diseases
Dr. Johannes Beckers  & Prof. Dr. Martin Hrabé de Angelis
Institute for Experimental Genetics
GSF - National Research Center for Environment and Health, Neuherberg

II. Functional Analysis of Protein Networks
Prof. Dr. Friedrich W. Herberg
Institute for Biochemistry, University of Kassel

III. Comparative Study of the Brain Proteome exposed to different neurodegenerative Diseases and different Drugs. Detecting Rules in Proteomic Networking
Prof. Dr. Dr. Joachim Klose
Institute for Human Genetics, Charité Berlin

IV. Cellular and Subcellular Neuroproteomics
Prof. Dr. Hans A. Kretzschmar , Dr. Anna Crecelius & Dr. Thomas Arzberger
Institute of Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich

V. Brain Proteomics - Quantitative Multi-dimensional LC-based Protein Analysis
Prof. Dr. Helmut E. Meyer & Jun.-Prof. Dr. Katrin Marcus
Medical Proteom-Center, Ruhr-University Bochum

VI. Analysis of Gene Expression in a Mouse Model of Parkinson's Disease and Identification of Target Proteins Involved in Disease Amelioration
Prof. Dr. Melitta Schachner
University Hospital Eppendorf, Hamburg

VII. Proteomics Imaging in Situ: Protein-Protein Networks and the Cellular Toponome of Neuronal Synapses in the CNS
Prof. Dr. Walter Schubert
Otto von Guericke University, Magdeburg

VIII. In Silico Modelling of Neurodegenerative Diseases
Dr. Johannes Schuchhardt
MicroDiscovery GmbH, Berlin

IX. Analysis of Brain Proteome Function in Cellular Model Systems
Dr. Marius Ueffing
GSF-National Research Center for Environment and Health, Neuherberg

X. Clinical Neuroproteomics of Dementias: Identification of Novel Biomarkers for their Early Diagnosis and Preventive Therapy
Prof. Dr. med. Jens Wiltfang & PD Dr. med. Piotr Lewczuk
Friedrich Alexander University of Erlangen-Nuremberg, Erlangen

XI. Administration and Projectdatabase
Prof. Dr. Helmut E. Meyer & Jun.-Prof. Dr. Katrin Marcus
Medical Proteom-Center, Ruhr-University Bochum

XII. Functional Analysis of Human and Ape Proteomes
Prof. Dr. Drs. h.c. Svante Pääbo
Department of Evolutionary Genetics
Max Planck Institute for Evolutionary Genetics, Leipzig